Sequence evolution and cross‐reactive antibody responses to hypervariable region 1 in acute hepatitis C virus infection
Identifieur interne : 003516 ( Main/Exploration ); précédent : 003515; suivant : 003517Sequence evolution and cross‐reactive antibody responses to hypervariable region 1 in acute hepatitis C virus infection
Auteurs : Sandra Hjalmarsson [Suède, États-Unis] ; Jonas Blomberg [Suède] ; Lena Grillner [Suède] ; Rüdiger Pipkorn [Suède] ; Tobias Allander [Suède, États-Unis]Source :
- Journal of Medical Virology [ 0146-6615 ] ; 2001-06.
English descriptors
- Teeft :
- Acute hepatitis, Acute infection, Allander, Amino, Amino acid sequences, Amino acid substitutions, Antibody, Antibody binding, Antibody reactivity, Antibody recognition, Antibody response, Antibody responses, Antibody titres, Antihvr1 response, Chronic cases, Chronic hepatitis, Chronic infection, Chronic patients, Clone, Consensus peptide sw1a, Consensus sequence, Different time points, Direct sequencing, Dominant sequence, Early antibody response, Envelope protein, Grant sponsor, Hepatitis, Humoral, Humoral immunity, Hvr1, Hvr1 peptides, Hvr1 sequence, Hvr1 sequences, Hvr1 variability, Hvr1 variant, Hvr1 variant peptides, Hvr1 variants, Hyperimmune serum, Hypervariable, Hypervariable region, Immune, Immune response, Individual clones, Infection, Initial response, Kato, Large number, Lymphocytic choriomeningitis virus infection, Medical sciences, Months post infection, Nosocomial outbreak, Optical density, Patient sera, Pbsm, Peak reactivity, Peptide, Peptide group, Possible interpretations, Present study, Proc natl acad, Protective immunity, Putative envelope glycoprotein, Quasispecies distribution, Reactive, Same virus strain, Sequence evolution, Sequence variation, Sequential sera, Sequential serum samples, Serum samples, Substitution, Swedish genotype, Swedish type, Synthetic peptides, Time point, Unrelated hvr1 sequences, Uppsala university hospital, Vaccine development, Variant, Viral, Viral clearance, Virol, Virus hypervariable region, Virus infection, Weak antibody binding.
Abstract
Hepatitis C virus (HCV) infection may result in acute resolving or chronic infection. Patients that clear the infection have a more vigorous cellular immune response and an early humoral response to the hypervariable region 1 (HVR1) of the E2 envelope protein. To analyse further the properties of the early anti‐HVR1 response, cross‐reactivity of anti‐HVR1 responses was assessed in five patients with acute HCV infection, who were infected by the same virus strain during a nosocomial outbreak . The sequence evolution of HVR1 was examined in sequential serum samples up to 37 months post infection. Peptides were synthesised corresponding to the obtained HVR1 sequences and unrelated HVR1 sequences, and antibody reactivity to the peptides in sequential sera was investigated by ELISA. The results suggest an association between specific gaps in humoral immunity and the HVR1 sequence evolution during early infection. Possible interpretations of this phenomenon include immune escape mechanisms or suppression of specific anti‐HVR1 antibodies. J. Med. Virol. 64:117–124, 2001. © 2001 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/jmv.1026
Affiliations:
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VIROLOGY</title><idno type="ISSN">0146-6615</idno><idno type="eISSN">1096-9071</idno><imprint><biblScope unit="vol">64</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="117">117</biblScope><biblScope unit="page" to="124">124</biblScope><biblScope unit="page-count">8</biblScope><publisher>John Wiley & Sons, Inc.</publisher><pubPlace>New York</pubPlace><date type="published" when="2001-06">2001-06</date></imprint><idno type="ISSN">0146-6615</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0146-6615</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acute hepatitis</term><term>Acute infection</term><term>Allander</term><term>Amino</term><term>Amino acid sequences</term><term>Amino acid substitutions</term><term>Antibody</term><term>Antibody binding</term><term>Antibody reactivity</term><term>Antibody recognition</term><term>Antibody response</term><term>Antibody responses</term><term>Antibody titres</term><term>Antihvr1 response</term><term>Chronic cases</term><term>Chronic hepatitis</term><term>Chronic infection</term><term>Chronic patients</term><term>Clone</term><term>Consensus peptide sw1a</term><term>Consensus sequence</term><term>Different time points</term><term>Direct sequencing</term><term>Dominant sequence</term><term>Early antibody response</term><term>Envelope protein</term><term>Grant sponsor</term><term>Hepatitis</term><term>Humoral</term><term>Humoral immunity</term><term>Hvr1</term><term>Hvr1 peptides</term><term>Hvr1 sequence</term><term>Hvr1 sequences</term><term>Hvr1 variability</term><term>Hvr1 variant</term><term>Hvr1 variant peptides</term><term>Hvr1 variants</term><term>Hyperimmune serum</term><term>Hypervariable</term><term>Hypervariable region</term><term>Immune</term><term>Immune response</term><term>Individual clones</term><term>Infection</term><term>Initial response</term><term>Kato</term><term>Large number</term><term>Lymphocytic choriomeningitis virus infection</term><term>Medical sciences</term><term>Months post infection</term><term>Nosocomial outbreak</term><term>Optical density</term><term>Patient sera</term><term>Pbsm</term><term>Peak reactivity</term><term>Peptide</term><term>Peptide group</term><term>Possible interpretations</term><term>Present study</term><term>Proc natl acad</term><term>Protective immunity</term><term>Putative envelope glycoprotein</term><term>Quasispecies distribution</term><term>Reactive</term><term>Same virus strain</term><term>Sequence evolution</term><term>Sequence variation</term><term>Sequential sera</term><term>Sequential serum samples</term><term>Serum samples</term><term>Substitution</term><term>Swedish genotype</term><term>Swedish type</term><term>Synthetic peptides</term><term>Time point</term><term>Unrelated hvr1 sequences</term><term>Uppsala university hospital</term><term>Vaccine development</term><term>Variant</term><term>Viral</term><term>Viral clearance</term><term>Virol</term><term>Virus hypervariable region</term><term>Virus infection</term><term>Weak antibody binding</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Hepatitis C virus (HCV) infection may result in acute resolving or chronic infection. Patients that clear the infection have a more vigorous cellular immune response and an early humoral response to the hypervariable region 1 (HVR1) of the E2 envelope protein. To analyse further the properties of the early anti‐HVR1 response, cross‐reactivity of anti‐HVR1 responses was assessed in five patients with acute HCV infection, who were infected by the same virus strain during a nosocomial outbreak . The sequence evolution of HVR1 was examined in sequential serum samples up to 37 months post infection. Peptides were synthesised corresponding to the obtained HVR1 sequences and unrelated HVR1 sequences, and antibody reactivity to the peptides in sequential sera was investigated by ELISA. The results suggest an association between specific gaps in humoral immunity and the HVR1 sequence evolution during early infection. Possible interpretations of this phenomenon include immune escape mechanisms or suppression of specific anti‐HVR1 antibodies. J. Med. Virol. 64:117–124, 2001. © 2001 Wiley‐Liss, Inc.</div></front></TEI><affiliations><list><country><li>Suède</li><li>États-Unis</li></country><region><li>Maryland</li><li>Svealand</li></region><settlement><li>Stockholm</li></settlement></list><tree><country name="Suède"><noRegion><name sortKey="Hjalmarsson, Sandra" sort="Hjalmarsson, Sandra" uniqKey="Hjalmarsson S" first="Sandra" last="Hjalmarsson">Sandra Hjalmarsson</name></noRegion><name sortKey="Allander, Tobias" sort="Allander, Tobias" uniqKey="Allander T" first="Tobias" last="Allander">Tobias Allander</name><name sortKey="Blomberg, Jonas" sort="Blomberg, Jonas" uniqKey="Blomberg J" first="Jonas" last="Blomberg">Jonas Blomberg</name><name sortKey="Grillner, Lena" sort="Grillner, Lena" uniqKey="Grillner L" first="Lena" last="Grillner">Lena Grillner</name><name sortKey="Pipkorn, Rudiger" sort="Pipkorn, Rudiger" uniqKey="Pipkorn R" first="Rüdiger" last="Pipkorn">Rüdiger Pipkorn</name></country><country name="États-Unis"><region name="Maryland"><name sortKey="Hjalmarsson, Sandra" sort="Hjalmarsson, Sandra" uniqKey="Hjalmarsson S" first="Sandra" last="Hjalmarsson">Sandra Hjalmarsson</name></region><name sortKey="Allander, Tobias" sort="Allander, Tobias" uniqKey="Allander T" first="Tobias" last="Allander">Tobias Allander</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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